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Protocol for identifying cell-type-specific genes associated with disease risk using single-cell eQTL data.

STAR protocols - 19 Jun 2026

Fang Xin, Bian Lijun, Yan Caiwang, Jin Guangfu

Abstract excerpt

Here, we present a protocol for mapping cell-type-specific cis-acting expression quantitative trait loci (cis-eQTLs) in a target tissue and integrating them with genome-wide association study (GWAS) data. We describe pooled-sample multiplexed sequencing, genotype-based cell demultiplexing, cis-eQTL detection in specific cell types, and integration of single-cell eQTLs with GWAS. This protocol facilitates the...

Topics

Quantitative Trait Loci
Genome-Wide Association Study
Single-Cell Analysis
Humans
Genetic Predisposition to Disease
Single-Cell Gene Expression Analysis
Polymorphism, Single Nucleotide

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 42101938
DOI: 10.1016/j.xpro.2026.104545
PMCID: PMC13156634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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