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Article

A computational method for cell type-specific expression quantitative trait loci mapping using bulk RNA-seq data.

Nature communications - 25 May 2023

Little Paul, Liu Si, Zhabotynsky Vasyl, Li Yun, Lin Dan-Yu, Sun Wei

Abstract excerpt

Mapping cell type-specific gene expression quantitative trait loci (ct-eQTLs) is a powerful way to investigate the genetic basis of complex traits. A popular method for ct-eQTL mapping is to assess the interaction between the genotype of a genetic locus and the abundance of a specific cell type using a linear model. However, this approach requires transforming RNA-seq count data, which distorts the relation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37231002
DOI: 10.1038/s41467-023-38795-w
PMCID: PMC10212972

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