Article

Leveraging cell-type specificity and similarity improves single-cell eQTL fine-mapping

2025-03-11

Abstract excerpt

Identifying cell-type-specific expression quantitative trait loci (eQTLs) is important to understanding the genetic regulation of gene expressions at the cell-type level and its relevance to complex traits. However, existing eQTL fine-mapping methods are limited in power and accuracy when cell types are analyzed separately. To improve eQTL mapping, we present CASE, a Bayesian framework to perform C ell-type-speci...

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Literature Corpus work: 70145e9d-c41d-5a0a-8927-a10a5831ee8b
DOI: 10.1101/2025.03.05.641709

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