Article

A computational method for Cell type-specific Expression Quantitative Trait Loci mapping using bulk RNA-seq data

2022-04-01

Abstract excerpt

Mapping cell type-specific gene expression quantitative trait loci (ct-eQTLs) is a powerful way to investigate the genetic basis of complex traits. A popular method for ct-eQTL mapping is to assess the interaction between the genotype of a genetic locus and the abundance of a specific cell type using a linear model. However, this approach requires transforming RNA-seq count data, which distorts the relation betwee...

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Literature Corpus work: dcf7300b-4482-5e98-9cf6-1e1a27123706
DOI: 10.1101/2022.03.31.486605

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