Article
Regulated translation initiation controls stress-induced gene expression in mammalian cells.
Molecular cell - 1 Nov 2000
Harding H P, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D
Abstract excerpt
Protein kinases that phosphorylate the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) are activated in stressed cells and negatively regulate protein synthesis. Phenotypic analysis of targeted mutations in murine cells reveals a novel role for eIF2alpha kinases in regulating gene expression in the unfolded protein response (UPR) and in amino acid starved cells. When activated by their cognate...
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