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Article

4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging.

The Journal of cell biology - 2 Jan 2017

Kang Min-Ji, Vasudevan Deepika, Kang Kwonyoon, Kim Kyunggon, Park Jung-Eun, Zhang Nan, Zeng Xiaomei, Neubert Thomas A, Marr Michael T, Ryoo Hyung Don

Abstract excerpt

Reduced amino acid availability attenuates mRNA translation in cells and helps to extend lifespan in model organisms. The amino acid deprivation-activated kinase GCN2 mediates this response in part by phosphorylating eIF2α. In addition, the cap-dependent translational inhibitor 4E-BP is transcriptionally induced to extend lifespan in Drosophila melanogaster, but through an unclear mechanism. Here, we show that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27979906
DOI: 10.1083/jcb.201511073
PMCID: PMC5223598

Genes

ATF4

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4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging.PMID 27979906Read ↗

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