Article
Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegans.
PLoS genetics - 1 Sept 2016
Cattie Douglas J, Richardson Claire E, Reddy Kirthi C, Ness-Cohn Elan M, Droste Rita, Thompson Mary K, Gilbert Wendy V, Kim Dennis H
Abstract excerpt
The translation initiation factor eIF3 is a multi-subunit protein complex that coordinates the assembly of the 43S pre-initiation complex in eukaryotes. Prior studies have demonstrated that not all subunits of eIF3 are essential for the initiation of translation, suggesting that some subunits may serve regulatory roles. Here, we show that loss-of-function mutations in the genes encoding the conserved eIF3k and...
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