Article
Bayesian modeling of skewed X inactivation in genetically diverse mice identifies a novel Xce allele associated with copy number changes.
Genetics - 17 May 2021
Sun Kathie Y, Oreper Daniel, Schoenrock Sarah A, McMullan Rachel, Giusti-Rodríguez Paola, Zhabotynsky Vasyl, Miller Darla R, Tarantino Lisa M, Pardo-Manuel de Villena Fernando, Valdar William
Abstract excerpt
Female mammals are functional mosaics of their parental X-linked gene expression due to X chromosome inactivation (XCI). This process inactivates one copy of the X chromosome in each cell during embryogenesis and that state is maintained clonally through mitosis. In mice, the choice of which parental X chromosome remains active is determined by the X chromosome controlling element (Xce), which has been mapped to...
Topics
- Alleles
- Animals
- Bayes Theorem
- Chromosome Mapping
- DNA Copy Number Variations
- Dosage Compensation, Genetic
- Genes, X-Linked
- Haplotypes
- Mice
- Mice, 129 Strain
- Mice, Inbred C57BL
- Mice, Inbred NOD
- Phylogeny