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Article

Genetic architecture of skewed X inactivation in the laboratory mouse.

PLoS genetics - 1 Jan 2013

Calaway John D, Lenarcic Alan B, Didion John P, Wang Jeremy R, Searle Jeremy B, McMillan Leonard, Valdar William, Pardo-Manuel de Villena Fernando

Abstract excerpt

X chromosome inactivation (XCI) is the mammalian mechanism of dosage compensation that balances X-linked gene expression between the sexes. Early during female development, each cell of the embryo proper independently inactivates one of its two parental X-chromosomes. In mice, the choice of which X chromosome is inactivated is affected by the genotype of a cis-acting locus, the X-chromosome controlling element...

Topics

Alleles
Animals
Chromosome Mapping
Dosage Compensation, Genetic
Female
Genes, X-Linked
Genetic Loci
Haplotypes
Mice
Phylogeny
RNA, Long Noncoding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

X Chromosome Inactivation

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Identifiers

PMID: 24098153
DOI: 10.1371/journal.pgen.1003853
PMCID: PMC3789830

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