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Article

LINE-1 repeats are a defining feature of the Xce.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2026

Jeon Yesu, Ji Fei, Das Priyojit, Wang Peggy I, Weissbein Uri, Carrette Lieselot L G, Kesner Barry, Sadreyev Ruslan, Lee Jeannie T

Abstract excerpt

During early development, female mammals inactivate one X chromosome to balance their X-linked gene dosage with males. While allelic choice is random in inbred mouse populations, choice can be significantly skewed in interstrain hybrids. The genetic basis of skewing has long been attributed to the mysterious "X chromosome controlling element(s)" (Xce) with different strengths among species, subspecies, and...

Read the complete abstract on PubMed

Topics

Animals
X Chromosome
Long Interspersed Nucleotide Elements
Mice
X Chromosome Inactivation
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

YY1 Transcription Factor

Gene Dosage

RNA, Long Noncoding

Alleles

Source

Open in PubMed Open full text

Identifiers

PMID: 42709804
DOI: 10.1073/pnas.2514037123
PMCID: PMC13578804

Genes

YY1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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