Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Re-defining synthetic lethality by phenotypic profiling for precision oncology.

Cell chemical biology - 18 Mar 2021

Akimov Yevhen, Aittokallio Tero

Abstract excerpt

High-throughput functional and genomic screening techniques provide systematic means for phenotypic discovery. Using synthetic lethality (SL) as a paradigm for anticancer drug and target discovery, we describe how these screening technologies may offer new possibilities to identify therapeutically relevant and selective SL interactions by addressing some of the challenges that have made robust discovery of SL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Discovery
Share to High-Throughput Screening Assays
Share to Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Precision Medicine

Source

Identifiers

PMID: 33631125
DOI: 10.1016/j.chembiol.2021.01.026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Re-defining synthetic lethality by phenotypic profiling for precision oncology.PMID 33631125Read ↗

The biological essence of synthetic lethality: Bringing new opportunities for cancer therapySemantic proximity Read ↗

A Methodological Workflow to Analyze Synthetic Lethality and Drug Synergism in Cancer Cells.Semantic proximity Read ↗

A lethal combination for cancer cells: synthetic lethality screenings for drug discovery.Semantic proximity Read ↗

Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation.Semantic proximity Read ↗

Development of synthetic lethality in cancer: molecular and cellular classification.Semantic proximity Read ↗

Synthetic Lethality in Cancer Therapeutics: The Next GenerationSemantic proximity Read ↗

Development of synthetic lethality anticancer therapeutics.Semantic proximity Read ↗

Cutting down the time to identify challenging tumor therapeutic targets and drug combinations using synthetic lethal approachesSemantic proximity Read ↗

Beyond synthetic lethality: charting the landscape of clinically relevant genetic interactions in cancerSemantic proximity Read ↗

The power and the promise of synthetic lethality for clinical application in cancer treatmentSemantic proximity Read ↗

Synthetic lethality-mediated precision oncology via the tumor transcriptomeSemantic proximity Read ↗

Leveraging microenvironmental synthetic lethalities to treat cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.