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Article

Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation.

Journal of hematology & oncology - 3 Sept 2020

Topatana Win, Juengpanich Sarun, Li Shijie, Cao Jiasheng, Hu Jiahao, Lee Jiyoung, Suliyanto Kenneth, Ma Diana, Zhang Bin, Chen Mingyu, Cai Xiujun

Abstract excerpt

Synthetic lethality is a lethal phenomenon in which the occurrence of a single genetic event is tolerable for cell survival, whereas the co-occurrence of multiple genetic events results in cell death. The main obstacle for synthetic lethality lies in the tumor biology heterogeneity and complexity, the inadequate understanding of synthetic lethal interactions, drug resistance, and the challenges regarding...

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Identifiers

PMID: 32883316
DOI: 10.1186/s13045-020-00956-5
PMCID: PMC7470446

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