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Leveraging microenvironmental synthetic lethalities to treat cancer

14 Mar 2021

Abstract excerpt

Treatment resistance leads to cancer patient mortality. Therapeutic approaches that employ synthetic lethality to target mutational vulnerabilities in key tumor cell signaling pathways have proven effective in overcoming therapeutic resistance in some cancers. Yet, tumors are organs composed of malignant cells residing within a cellular and noncellular stroma. Tumor evolution and resistance to anticancer...

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PMID: 33720045
DOI: 10.1172/jci143765

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