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Article

Development of synthetic lethality anticancer therapeutics.

Journal of medicinal chemistry - 9 Oct 2014

Fang Bingliang

Abstract excerpt

The concept of synthetic lethality (the creation of a lethal phenotype from the combined effects of mutations in two or more genes) has recently been exploited in various efforts to develop new genotype-selective anticancer therapeutics. These efforts include screening for novel anticancer agents, identifying novel therapeutic targets, characterizing mechanisms of resistance to targeted therapy, and improving...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24893124
DOI: 10.1021/jm500415t
PMCID: PMC4205018

Genes

BRCA1
BRCA2

Provenance

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