Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Asynchronous replication of imprinted genes is established in the gametes and maintained during development.

Nature - 28 Oct 1999

Simon I, Tenzen T, Reubinoff B E, Hillman D, McCarrey J R, Cedar H

Abstract excerpt

Genomic imprinting is characterized by allele-specific expression of multiple genes within large chromosomal domains that undergo DNA replication asynchronously during S phase. Here we show, using both fluorescence in situ hybridization analysis and S-phase fractionation techniques, that differential replication timing is associated with imprinted genes in a variety of cell types, and is already present in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantigens
Share to Embryonic Development
Share to Oogenesis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ribonucleoproteins, Small Nuclear

Share to S Phase

Share to snRNP Core Proteins

Share to Spermatogenesis

Source

Identifiers

PMID: 10553911
DOI: 10.1038/44866

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Asynchronous replication of imprinted genes is established in the gametes and maintained during development.PMID 10553911Read ↗

Reprogramming of DNA replication timing.Semantic proximity Read ↗

Allele-specific replication timing of imprinted gene regions.Semantic proximity Read ↗

Parent-of-origin-specific DNA replication timing is confined to large imprinted regions.Semantic proximity Read ↗

Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization.Semantic proximity Read ↗

Chromosomal coordination and differential structure of asynchronous replicating regions.Semantic proximity Read ↗

Replication timing properties within the mouse distal chromosome 7 imprinting cluster.Semantic proximity Read ↗

CTCF regulates asynchronous replication of the imprinted H19/Igf2 domain.Semantic proximity Read ↗

Allele-specific genome-wide profiling in human primary erythroblasts reveal replication program organization.Semantic proximity Read ↗

Factors affecting the timing and imprinting of replication on a mammalian chromosomeSemantic proximity Read ↗

Single cell multiomics approach to analyze replication timing and gene expression in mouse preimplantation embryosSemantic proximity Read ↗

Reverse replication timing for the XIST gene in human fibroblasts.Semantic proximity Read ↗

Sex-specific DNA-replication in the early mammalian embryoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.