Article
Coordination of the random asynchronous replication of autosomal loci.
Nature genetics - 1 Mar 2003
Singh Nandita, Ebrahimi Farah A W, Gimelbrant Alexander A, Ensminger Alexander W, Tackett Michael R, Qi Peimin, Gribnau Joost, Chess Andrew
Abstract excerpt
Random monoallelic expression and asynchronous replication define an unusual class of autosomal mammalian genes. We show that every cell has randomly chosen either the maternal or paternal copy of each given autosome pair, such that alleles of these genes scattered across the chosen chromosome replicate earlier than the alleles on the homologous chromosome. Thus, chromosome-pair non-equivalence, rather than being...
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