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Article

Programming asynchronous replication in stem cells.

Nature structural & molecular biology - 1 Dec 2017

Masika Hagit, Farago Marganit, Hecht Merav, Condiotti Reba, Makedonski Kirill, Buganim Yosef, Burstyn-Cohen Tal, Bergman Yehudit, Cedar Howard

Abstract excerpt

Many regions of the genome replicate asynchronously and are expressed monoallelically. It is thought that asynchronous replication may be involved in choosing one allele over the other, but little is known about how these patterns are established during development. We show that, unlike somatic cells, which replicate in a clonal manner, embryonic and adult stem cells are programmed to undergo switching, such that...

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Identifiers

PMID: 29131141
DOI: 10.1038/nsmb.3503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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