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Article

Investigation of the aquaporin-2 gating mechanism with molecular dynamics simulations.

Proteins - 1 Jul 2021

Hadidi Hooman, Kamali Reza, Binesh Alireza

Abstract excerpt

Aquaporin-2 plays a vital role in the human kidney as a water passage channel. Any disorder with its function can cause water imbalance and consequently disease in humans, especially nephrogenic diabetes insipidus (NDI). For this reason, an accurate understanding of its performance can be useful for therapeutic purposes. In this article, we investigate the gating mechanism induced by spontaneous fluctuations in...

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Identifiers

PMID: 33576101
DOI: 10.1002/prot.26061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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