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Article

Insights from studying the mutation-induced allostery in the M2 proton channel by molecular dynamics.

Protein engineering, design & selection : PEDS - 1 Aug 2010

Wang Jing-Fang, Chou Kuo-Chen

Abstract excerpt

As an essential component of the viral envelope, M2 proton channel plays a central role in the virus replications and has been a key target for drug design against the influenza A viruses. The adamantadine-based drugs, such as amantadine and rimantadine, were developed for blocking the channel so as to suppress the replication of viruses. However, patients, especially those infected by the H1N1 influenza A...

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Identifiers

PMID: 20571121
DOI: 10.1093/protein/gzq040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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