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Molecular mechanism of water and glycerol transport through hydrophobic selectivity filter in the aquaporin homolog of <i>Trypanosoma brucei</i>

2026-05-01

Abstract excerpt

The protozoan parasite Trypanosoma brucei is implicated in deadly African sleeping sickness. Experimental studies show that T. brucei codes for three aquaporin homologs (TbAQP1 to TbAQP3). TbAQP2 has been established as the high affinity drug transporter of drugs pentamidine and melarsoprol. Mutation in TbAQP2 or its loss result in pentamidine-melarsoprol cross-resistance. TbAQP2 is also shown to transport water...

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Literature Corpus work
004dac56-3b60-5ffe-b8e6-f02f8e22362e
DOI
10.64898/2026.04.27.720980
Open publication

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Molecular mechanism of water and glycerol transport through hydrophobic selectivity filter in the aquaporin homolog of <i>Trypanosoma brucei</i>DOI 10.64898/2026.04.27.720980
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