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Article

Molecular mechanism of anion permeation through aquaporin 6.

Biophysical journal - 20 Aug 2024

Yamamoto Eiji, Joo Keehyoung, Lee Jooyoung, Sansom Mark S P, Yasui Masato

Abstract excerpt

Aquaporins (AQPs) are recognized as transmembrane water channels that facilitate selective water permeation through their monomeric pores. Among the AQP family, AQP6 has an intriguing characteristic as an anion channel, which is allosterically controlled by pH conditions and is eliminated by a single amino acid mutation. However, the molecular mechanism of anion permeation through AQP6 remains unclear. Using...

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Identifiers

PMID: 38894539
DOI: 10.1016/j.bpj.2024.06.013
PMCID: PMC11365104

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