Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mechanism of Na⁺/K⁺ selectivity in mammalian voltage-gated sodium channels based on molecular dynamics simulation.

Biophysical journal - 4 Jun 2013

Xia Mengdie, Liu Huihui, Li Yang, Yan Nieng, Gong Haipeng

Abstract excerpt

Voltage-gated sodium (Nav) channels and their Na⁺/K⁺ selectivity are of great importance in the mammalian neuronal signaling. According to mutational analysis, the Na⁺/K⁺ selectivity in mammalian Nav channels is mainly determined by the Lys and Asp/Glu residues located at the constriction site within the selectivity filter. Despite successful molecular dynamics simulations conducted on the prokaryotic Nav...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Molecular Dynamics Simulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Permeability

Share to Potassium

Share to Protein Conformation

Share to Sodium

Share to Substrate Specificity

Share to Voltage-Gated Sodium Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 23746512
DOI: 10.1016/j.bpj.2013.04.035
PMCID: PMC3672897

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mechanism of Na⁺/K⁺ selectivity in mammalian voltage-gated sodium channels based on molecular dynamics simulation.PMID 23746512Read ↗

Selective ion permeation involves complexation with carboxylates and lysine in a model human sodium channel.Semantic proximity Read ↗

The structural basis of divalent cation block in a tetrameric prokaryotic sodium channel.Semantic proximity Read ↗

"Virtual patch clamp analysis" for predicting the functional significance of pathogenic variants in sodium channels.Semantic proximity Read ↗

A flexible GAS belt responds to pore mutations changing the ion selectivity of proton-gated channels.Semantic proximity Read ↗

Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?Semantic proximity Read ↗

Molecular simulation assisted identification of Ca(2+) binding residues in TMEM16A.Semantic proximity Read ↗

Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.Semantic proximity Read ↗

Structural insights in the permeation mechanism of an activated GIRK2 channel.Semantic proximity Read ↗

[Analysis of the Divalent Cation Blocking in Ion Channels by Crystal Structure and Molecular Dynamics Simulations].Semantic proximity Read ↗

Molecular basis of ion permeability in a voltage-gated sodium channel.Semantic proximity Read ↗

Structure-function analysis of the lithium-ion selectivity of the voltage-gated sodium channel.Semantic proximity Read ↗

Structures of closed and open states of a voltage-gated sodium channel.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.