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Article

Molecular dynamics study of water transport through AQP5-R188C mutant causing palmoplantar keratoderma (PPK) using the gating mechanism concept.

Biophysical chemistry - 1 Oct 2021

Hadidi Hooman, Kamali Reza

Abstract excerpt

It is widely known that any disruption to the water regulation in aquaporins (AQPs) leads to numerous important diseases. However, studies of dynamics and energetics of disease-causing mutations in the aquaporins on the molecular level are still limited. In the present work, the effects of a skin disease-causing mutant, R188C, on the structure of AQP5 and water transport mechanism within this mutated aquaporin...

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Identifiers

PMID: 34225022
DOI: 10.1016/j.bpc.2021.106655

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