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Article

Structural insights in the permeation mechanism of an activated GIRK2 channel.

Biochimica et biophysica acta. Biomembranes - 1 Jan 2024

Li Dailin, Shi Dingyuan, Wang Lei

Abstract excerpt

G protein-gated inwardly rectifying potassium (GIRK) channels play a significant role in physiopathology by the regulation of cell excitability. This regulation depends on the K+ ion conduction induced by structural constrictions: the selectivity filters (SFs), helix bundle crossings (HBCs), and G-loop gates. To explore why no permeation occurred when the constrictions were kept in the open state, a 4-K+-related...

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PMID: 37739205
DOI: 10.1016/j.bbamem.2023.184231

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