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Article

UNC-16/JIP3 and UNC-76/FEZ1 limit the density of mitochondria in C. elegans neurons by maintaining the balance of anterograde and retrograde mitochondrial transport.

Scientific reports - 12 Jun 2018

Sure Guruprasada Reddy, Chatterjee Anusheela, Mishra Nikhil, Sabharwal Vidur, Devireddy Swathi, Awasthi Anjali, Mohan Swetha, Koushika Sandhya P

Abstract excerpt

We investigate the role of axonal transport in regulating neuronal mitochondrial density. We show that the density of mitochondria in the touch receptor neuron (TRN) of adult Caenorhabditis elegans is constant. Mitochondrial density and transport are controlled both by the Kinesin heavy chain and the Dynein-Dynactin complex. However, unlike in other models, the presence of mitochondria in C. elegans TRNs depends...

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Source

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Identifiers

PMID: 29895958
DOI: 10.1038/s41598-018-27211-9
PMCID: PMC5997755

Genes

FEZ1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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