Article
Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans.
eLife - 6 Mar 2013
Yan Jing, Chao Dan L, Toba Shiori, Koyasako Kotaro, Yasunaga Takuo, Hirotsune Shinji, Shen Kang
Abstract excerpt
In neurons, microtubules (MTs) span the length of both axons and dendrites, and the molecular motors use these intracellular 'highways' to transport diverse cargo to the appropriate subcellular locations. Whereas axonal MTs are organized such that the plus-end is oriented out from the cell body, dendrites exhibit a mixed MTs polarity containing both minus-end-out and plus-end-out MTs. The molecular mechanisms...
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