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Article

Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter.

Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2012

Chua John Jia En, Butkevich Eugenia, Worseck Josephine M, Kittelmann Maike, Grønborg Mads, Behrmann Elmar, Stelzl Ulrich, Pavlos Nathan J, Lalowski Maciej M, Eimer Stefan, Wanker Erich E, Klopfenstein Dieter Robert, Jahn Reinhard

Abstract excerpt

Presynaptic nerve terminals are formed from preassembled vesicles that are delivered to the prospective synapse by kinesin-mediated axonal transport. However, precisely how the various cargoes are linked to the motor proteins remains unclear. Here, we report a transport complex linking syntaxin 1a (Stx) and Munc18, two proteins functioning in synaptic vesicle exocytosis at the presynaptic plasma membrane, to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22451907
DOI: 10.1073/pnas.1113819109
PMCID: PMC3326461

Genes

FEZ1

Variants

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter.PMID 22451907Read ↗

Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking.Semantic proximity Read ↗

UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin.Semantic proximity Read ↗

Kinesin-1 acts with netrin and DCC to maintain sensory neuron position in Caenorhabditis elegans.Semantic proximity Read ↗

UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly.Semantic proximity Read ↗

Synapse-Assembly Proteins Maintain Synaptic Vesicle Cluster Stability and Regulate Synaptic Vesicle Transport in Caenorhabditis elegans.Semantic proximity Read ↗

CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon.Semantic proximity Read ↗

The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans.Semantic proximity Read ↗

The kinesin-associated protein UNC-76 is required for axonal transport in the Drosophila nervous system.Semantic proximity Read ↗

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.Semantic proximity Read ↗

Kinesins in Caenorhabditis elegans neuronal morphogenesis.Semantic proximity Read ↗

Regulation of retrograde signaling at neuromuscular junctions by the novel C2 domain protein AEX-1.Semantic proximity Read ↗

Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursorsSemantic proximity Read ↗

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