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Article

Identification of an axonal kinesin-3 motor for fast anterograde vesicle transport that facilitates retrograde transport of neuropeptides.

Molecular biology of the cell - 1 Jan 2008

Barkus Rosemarie V, Klyachko Olga, Horiuchi Dai, Dickson Barry J, Saxton William M

Abstract excerpt

A screen for genes required in Drosophila eye development identified an UNC-104/Kif1 related kinesin-3 microtubule motor. Analysis of mutants suggested that Drosophila Unc-104 has neuronal functions that are distinct from those of the classic anterograde axonal motor, kinesin-1. In particular, unc-104 mutations did not cause the distal paralysis and focal axonal swellings characteristic of kinesin-1 (Khc)...

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Identifiers

PMID: 17989365
DOI: 10.1091/mbc.e07-03-0261
PMCID: PMC2174192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of an axonal kinesin-3 motor for fast anterograde vesicle transport that facilitates retrograde transport of neuropeptides.PMID 17989365Read ↗

Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans.Semantic proximity Read ↗

Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila.Semantic proximity Read ↗

Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursorsSemantic proximity Read ↗

CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon.Semantic proximity Read ↗

Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport.Semantic proximity Read ↗

Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons.Semantic proximity Read ↗

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Kinesin light chains are essential for axonal transport in Drosophila.Semantic proximity Read ↗

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ALS-Associated KIF5A Mutation Causes Locomotor Deficits Associated with Cytoplasmic Inclusions, Alterations of Neuromuscular Junctions, and Motor Neuron Loss.Semantic proximity Read ↗

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