Article

PPT1 Deficiency-Induced GABAAR Hyperpalmitoylation Impairs Synaptic Transmission and Memory Formation

2022-03-24

Abstract excerpt

<title>Abstract</title> <p>Palmitoylation is a reversible and dynamic process involving addition of palmitic acid to cysteine residues of proteins. Studies have indicated that a variety of neuronal receptors, including glutamate receptors such as AMPAR, NMDAR, and GABA<sub>A</sub>R, are palmitoylated, which contributes to the dynamic modulation of synaptic strength in response to neuronal activity. However, littl...

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Literature Corpus work: 6e2c0dcd-129f-571d-a4c3-7227ee661bef
DOI: 10.21203/rs.3.rs-860958/v2

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