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Article

Dysregulated GluA2-Y876 phosphorylation contributes to loss of synaptic upscaling in GRIP1 mutant mice with reduced sociability and increased repetitive behavior.

Molecular psychiatry - 1 May 2026

Han Mei, Tan Han L, Mejías Rebeca, Chiu Shu-Ling, Kim Juhyun, Huganir Richard L, Wang Tao

Abstract excerpt

Loss of synaptic upscaling, a post-synaptic homeostatic plasticity, has been reported in mouse models of autism, but the underlying mechanism remains unknown. Glutamate receptor interacting protein 1 (GRIP1) binds AMPA receptor 2 (GluA2) through its PDZ domains 4-6 where gain-of-function variants were described in autism. We characterized mice carrying one variant, GRIP1-I586L (murine I507L), that shows increased...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41390787
DOI: 10.1038/s41380-025-03415-0
PMCID: PMC12888764

Genes

GRIP1

Variants

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