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Article

Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity.

Learning & memory (Cold Spring Harbor, N.Y.) - 1 Jan 2000

Boehm Jannic, Ehrlich Ingrid, Hsieh Helen, Malinow Roberto

Abstract excerpt

The regulated trafficking of GluR1 contributes significantly to synaptic plasticity, but studies addressing the function of the GluR1 C-terminal PDZ-ligand domain in this process have produced conflicting results. Here, we resolve this conflict by showing that apparently similar C-terminal mutations of the GluR1 PDZ-ligand domain result in opposite physiological phenotypes during activity- and CamKII-induced...

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Identifiers

PMID: 16980545
DOI: 10.1101/lm.253506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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