Article

Type I TARPs regulate Kv7.2 potassium channels and susceptibility to seizures

2024-08-10

Abstract excerpt

<h4>Summary</h4> The M-current is a low-threshold potassium current that modulates neuronal excitability and suppresses repetitive firing. However, the mechanisms regulating M-channel function remain unclear. We identified type I Transmembrane AMPA receptor Regulatory Proteins (TARPs) as M-channel Kv7.2 subunit interactors in cortical neurons, with their interaction increasing upon neuronal depolarization. Co-exp...

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Literature Corpus work: 7f50c5b1-9e1c-56c2-a6a8-a5e1e0807d50
DOI: 10.1101/2024.08.09.607194

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