Article
Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP.
EMBO molecular medicine - 1 Jan 2016
Vogt Johannes, Yang Jenq-Wei, Mobascher Arian, Cheng Jin, Li Yunbo, Liu Xingfeng, Baumgart Jan, Thalman Carine, Kirischuk Sergei, Unichenko Petr, Horta Guilherme, Radyushkin Konstantin, Stroh Albrecht, Richers Sebastian, Sahragard Nassim, Distler Ute, Tenzer Stefan, Qiao Lianyong, Lieb Klaus, Tüscher Oliver, Binder Harald, Ferreiros Nerea, Tegeder Irmgard, Morris Andrew J, Gropa Sergiu, Nürnberg Peter, Toliat Mohammad R, Winterer Georg, Luhmann Heiko J, Huai Jisen, Nitsch Robert
Abstract excerpt
Loss of plasticity-related gene 1 (PRG-1), which regulates synaptic phospholipid signaling, leads to hyperexcitability via increased glutamate release altering excitation/inhibition (E/I) balance in cortical networks. A recently reported SNP in prg-1 (R345T/mutPRG-1) affects ~5 million European and US citizens in a monoallelic variant. Our studies show that this mutation leads to a loss-of-PRG-1 function at the...
Topics
- Animals
- Electroencephalography
- Evoked Potentials
- Glycosylation
- HEK293 Cells
- Humans
- Lysophospholipids
- Mental Disorders