Article

PP1β opposes classic PP1 function, inhibiting spine maturation and promoting LTP

2023-01-27

Abstract excerpt

<h4>Summary</h4> Protein phosphatase 1 (PP1) regulates synaptic plasticity and has been described as a molecular constraint on learning and memory. There are three neuronal isoforms, PP1α, PP1β, and PP1γ, but little is known about their individual functions. PP1α and PP1γ are assumed to mediate the effects of PP1 on learning and memory based on their enrichment at dendritic spines and their preferential binding t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0b2856e5-6aad-5efa-a9f9-6a4b79bfd295
DOI: 10.1101/2023.01.26.525737

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PP1β opposes classic PP1 function, inhibiting spine maturation and promoting LTPDOI 10.1101/2023.01.26.525737Read

Neuronal protein phosphatase 1β regulates glutamate release, cortical myelination, node of Ranvier formation, and action potential propagation in the optic nerveSemantic proximity Read

Actin-associated neurabin-protein phosphatase-1 complex regulates hippocampal plasticity.Semantic proximity Read

Partial inhibition of PP1 alters bidirectional synaptic plasticity in the hippocampus.Semantic proximity Read

A protein phosphatase-1gamma1 isoform selectivity determinant in dendritic spine-associated neurabin.Semantic proximity Read

SIPA1L1/SPAR1 is a non-PSD protein involved in GPCR signalingSemantic proximity Read

Slc20a1 and Slc20a2 Regulate Neuronal Plasticity and Cognition Independently of Their Phosphate Transport AbilitySemantic proximity Read

Aβ Oligomer-Mediated Long-Term Potentiation Impairment Involves Protein Phosphatase 1-Dependent MechanismsSemantic proximity Read

NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca²⁺-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin.Semantic proximity Read

Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory.Semantic proximity Read

SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairmentSemantic proximity Read

MARK1 regulates dendritic spine morphogenesis and cognitive functions <i>in vivo</i>Semantic proximity Read

Protein Phosphatase 2A (PP2A) mutations in brain function, development, and neurologic disease.Semantic proximity Read