Article
Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Aug 2008
Zhang Chuan-Sheng, Bertaso Federica, Eulenburg Volker, Lerner-Natoli Mireille, Herin Greta Ann, Bauer Liane, Bockaert Joel, Fagni Laurent, Betz Heinrich, Scheschonka Astrid
Abstract excerpt
The metabotropic glutamate receptor 7 (mGluR7) is widely expressed throughout the brain and primarily localized at presynaptic active zones, where it is thought to regulate neurotransmitter release. Protein interacting with C kinase 1 (PICK1), a postsynaptic density protein-95/disc-large tumor suppressor protein/zonula occludens-1 (PDZ)-domain protein, binds to the three C-terminal amino acids (-LVI) of the...
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