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Article

Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory.

Cell - 7 Mar 2003

Lee Hey-Kyoung, Takamiya Kogo, Han Jung-Soo, Man Hengye, Kim Chong-Hyun, Rumbaugh Gavin, Yu Sandy, Ding Lin, He Chun, Petralia Ronald S, Wenthold Robert J, Gallagher Michela, Huganir Richard L

Abstract excerpt

Plasticity of the nervous system is dependent on mechanisms that regulate the strength of synaptic transmission. Excitatory synapses in the brain undergo long-term potentiation (LTP) and long-term depression (LTD), cellular models of learning and memory. Protein phosphorylation is required for the induction of many forms of synaptic plasticity, including LTP and LTD. However, the critical kinase substrates that...

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PMID: 12628184
DOI: 10.1016/s0092-8674(03)00122-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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