Article
Genetically determined blood pressure, antihypertensive medications, and risk of Alzheimer's disease: a Mendelian randomization study.
Alzheimer's research & therapy - 9 Feb 2021
Ou Ya-Nan, Yang Yu-Xiang, Shen Xue-Ning, Ma Ya-Hui, Chen Shi-Dong, Dong Qiang, Tan Lan, Yu Jin-Tai
Abstract excerpt
BACKGROUND: Observational studies suggest that the use of antihypertensive medications (AHMs) is associated with a reduced risk of Alzheimer's disease (AD); however, these findings may be biased by confounding and reverse causality. We aimed to explore the effects of blood pressure (BP) and lowering systolic BP (SBP) via the protein targets of different AHMs on AD through a two-sample Mendelian randomization (MR)...
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