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Genetic proxies for antihypertensive drugs and mental disorders: Mendelian randomization study in European and East Asian populations

2 Jan 2024

Abstract excerpt

BACKGROUND: Mental disorders are among the top causes of disease burden worldwide. Existing evidence regarding the repurposing of antihypertensives for mental disorders treatment is conflicting and cannot establish causation. METHODS: We used Mendelian randomization to assess the effects of angiotensin-converting-enzyme inhibitors (ACEIs), beta blockers (BBs), and calcium channel blockers (CCBs) on risk of...

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PMID: 38166843
DOI: 10.1186/s12916-023-03218-6

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