Relationship between diastolic blood pressure and Alzheimer disease: A 2-sample Mendelian randomization study based on an automated screening method for exposure factors and empirical validation.

Abstract excerpt

This study investigates the causal relationship between diastolic blood pressure (DBP) and Alzheimer disease (AD) using 2-sample Mendelian randomization (MR) analysis with publicly available genome-wide association study (GWAS) data and empirical validation. Automated screening identified DBP as a factor related to AD. Two-sample MR analyses were conducted using inverse variance weighting (IVW), MR-Egger...

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• Aged
• Alzheimer Disease
• Blood Pressure
• Genome-Wide Association Study
• Mendelian Randomization Analysis