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Repurposing antihypertensive drugs for the prevention of Alzheimer’s disease: a Mendelian randomization study

4 Jul 2019

Abstract excerpt

BACKGROUND: Evidence concerning the potential repurposing of antihypertensives for Alzheimer's disease prevention is inconclusive. We used Mendelian randomization, which can be more robust to confounding by indication and patient characteristics, to investigate the effects of lowering systolic blood pressure, via the protein targets of different antihypertensive drug classes, on Alzheimer's disease. METHODS: We...

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PMID: 31335937
DOI: 10.1093/ije/dyz155

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