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Article

Causal Effects Between Blood Pressure Variability and Alzheimer's Disease: A Two-Sample Mendelian Randomization Study.

Journal of clinical hypertension (Greenwich, Conn.) - 1 May 2025

Jia Pingping, Hao Ziyu, Yiu Karen, Tsoi Kelvin

Abstract excerpt

Alzheimer's disease (AD), an escalating global public health concern, demonstrates complex pathogenesis involving both genetic predisposition and vascular components. Blood pressure variability (BPV) has been implicated in neurodegenerative diseases, but its causal relationship with AD remains unclear. This study aims to explore the causal relationship between BPV and AD by applying Mendelian randomization (MR)...

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Identifiers

PMID: 40346856
DOI: 10.1111/jch.70066
PMCID: PMC12064930

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