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Article

Class-Specific Antihypertensives and Alzheimer's Disease: Genotype- and Hypertension-Stratified Analysis.

Molecular neurobiology - 10 Mar 2026

Yang Dehao, Wei Ruting, Zhu Jinrong, Chen Jiaxuan, Wang Shiyue, Cai Hejia, Zhang Bo, Teng Bingxin, Li Bohao, Xie Xiaoya, Huang Suwen, Weng Yiyun, Chen Guangyong

Abstract excerpt

Antihypertensive medications (AHMs) may modulate Alzheimer's disease (AD) pathogenesis via cerebrovascular or neuroinflammatory pathways, yet evidence remains conflicting. This study investigated causal associations between AHM use and AD risk, focusing on drug classes, blood pressure status, and apolipoprotein E epsilon 4 (APOE ε4) effects. We integrated genetic causal inference with longitudinal survival...

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PMID: 41806233
DOI: 10.1007/s12035-026-05784-1

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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