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Exome-Wide Association Study Identified Clusters of Pleiotropic Genetic Associations with Alzheimer's Disease and Thirteen Cardiovascular Traits.

Genes - 22 Sept 2023

Loika Yury, Loiko Elena, Culminskaya Irina, Kulminski Alexander M

Abstract excerpt

Alzheimer's disease (AD) and cardiovascular traits might share underlying causes. We sought to identify clusters of cardiovascular traits that share genetic factors with AD. We conducted a univariate exome-wide association study and pair-wise pleiotropic analysis focused on AD and 16 cardiovascular traits-6 diseases and 10 cardio-metabolic risk factors-for 188,260 UK biobank participants. Our analysis pinpointed...

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PMID: 37895183
DOI: 10.3390/genes14101834
PMCID: PMC10606283

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