Article

Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer’s Disease

2024-08-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The genetic component of early-onset Alzheimer’s disease (EOAD), accounting for ∼10% of all Alzheimer’s disease (AD) cases, is largely unexplained. Recent studies suggest that EOAD may be enriched for variants acting in the lipid pathway. <h4>Objective</h4> To examine the shared genetic heritability between EOAD and the lipid pathway by genome-wide multi-trait genetic covarian...

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Literature Corpus work: 98a8889f-908e-5972-a76b-94239ca5a54e
DOI: 10.1101/2024.08.14.24311996

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