Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer's Disease.

PLoS genetics - 1 Mar 2025

Ray Nicholas R, Bradley Joseph, Yilmaz Elanur, Kizil Caghan, Kurup Jiji T, Martin Eden R, Klein Hans-Ulrich, Kunkle Brian W, Bennett David A, De Jager Philip L, Beecham Gary W, Cruchaga Carlos, Reitz Christiane

Abstract excerpt

The genetic component of early-onset Alzheimer disease (EOAD), accounting for ~10% of all Alzheimer's disease (AD) cases, is largely unexplained. Recent studies suggest that EOAD may be enriched for variants acting in the lipid pathway. The current study examines the shared genetic heritability between EOAD and the lipid pathway using genome-wide multi-trait genetic covariance analyses. Summary statistics were...

Read the complete abstract on PubMed

Topics

Humans
Alzheimer Disease
Genome-Wide Association Study
Quantitative Trait Loci
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Lipids

Polymorphism, Single Nucleotide

Linkage Disequilibrium

Lipid Metabolism

Age of Onset

Male

Female

DNA Methylation

Receptors, Immunologic

Source

Open in PubMed Open full text

Identifiers

PMID: 40096060
DOI: 10.1371/journal.pgen.1011631
PMCID: PMC11984970

Genes

APOE
CUZD1
LILRA5
MS4A4E
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer's Disease.PMID 40096060Read ↗

Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer’s DiseaseSemantic proximity Read ↗

Investigating Genetic Overlap between Alzheimer's Disease, Lipids, and Coronary Artery Disease: A Large-Scale Genome-Wide Cross Trait Analysis.Semantic proximity Read ↗

Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimer’s disease riskSemantic proximity Read ↗

Exome-Wide Association Study Identified Clusters of Pleiotropic Genetic Associations with Alzheimer's Disease and Thirteen Cardiovascular Traits.Semantic proximity Read ↗

Multi-class Modeling Identifies Shared Genetic Risk for Late-onset Epilepsy and Alzheimer’s DiseaseSemantic proximity Read ↗

Genetics of Late‐Onset Alzheimer′s Disease: Update from the Alzgene Database and Analysis of Shared PathwaysSemantic proximity Read ↗

A powerful approach to estimating annotation-stratified genetic covariance using GWAS summary statisticsSemantic proximity Read ↗

Integrative multi-omics approaches identify molecular pathways and improve Alzheimer's disease risk prediction.Semantic proximity Read ↗

A Powerful Approach to Estimating Annotation-Stratified Genetic Covariance via GWAS Summary Statistics.Semantic proximity Read ↗

Investigating genetic overlap between Alzheimer's disease, lipids, and coronary artery disease: a large-scale genome-wide cross trait analysisSemantic proximity Read ↗

Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways.Semantic proximity Read ↗

Multi-trait association studies discover pleiotropic loci between Alzheimer's disease and cardiometabolic traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.