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Article

Identification of shared genetic etiology of cardiovascular and cerebrovascular diseases through common cardiometabolic risk factors.

Communications biology - 27 Dec 2024

Ding Kexin, Qin Xueying, Wang Huairong, Wang Kun, Kang Xiaoying, Yu Yao, Liu Yang, Gong Haiying, Wu Tao, Chen Dafang, Hu Yonghua, Wang Tao, Wu Yiqun

Abstract excerpt

Cardiovascular diseases (CVDs) and cerebrovascular diseases (CeVDs) are closely related vascular diseases, sharing common cardiometabolic risk factors (RFs). Although pleiotropic genetic variants of these two diseases have been reported, their underlying pathological mechanisms are still unclear. Leveraging GWAS summary data and using genetic correlation, pleiotropic variants identification, and colocalization...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39730871
DOI: 10.1038/s42003-024-07417-6
PMCID: PMC11680921

Genes

CASZ1
GOSR2
RPRML
ABO
CDKN1A
CDKN2B
FES
LDLR
SH2B3
SWAP70
TWIST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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