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Article

A Bioassay Using a Pentadecanal Derivative to Measure S1P Lyase Activity.

International journal of molecular sciences - 1 Feb 2021

Shin Kyong-Oh, Shamshiddinova Maftuna, Lee Jung-No, Lee Kwang-Sik, Lee Yong-Moon

Abstract excerpt

Sphingosine-1-phosphate (S1P) is a unique lipid ligand binding to S1P receptors to transduce various cell survival or proliferation signals via small G proteins. S1P lyase (S1PL) is the specific enzyme that degrades S1P to phosphoethanolamine and (2E)-hexadecenal and therefore regulates S1P levels. S1PL also degrades dihydrosphingosine-1-phosphate (Sa1P), with a higher affinity to produce hexadecanal. Here, we...

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PMID: 33535437
DOI: 10.3390/ijms22031438
PMCID: PMC7867068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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