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Article

Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor.

PLoS genetics - 10 Feb 2011

Kennedy Michael A, Kabbani Nazir, Lambert Jean-Philippe, Swayne Leigh Anne, Ahmed Fida, Figeys Daniel, Bennett Steffany A L, Bryan Jennnifer, Baetz Kristin

Abstract excerpt

During Alzheimer's Disease, sustained exposure to amyloid-β₄₂ oligomers perturbs metabolism of ether-linked glycerophospholipids defined by a saturated 16 carbon chain at the sn-1 position. The intraneuronal accumulation of 1-O-hexadecyl-2-acetyl-sn-glycerophosphocholine (C16:0 PAF), but not its immediate precursor 1-O-hexadecyl-sn-glycerophosphocholine (C16:0 lyso-PAF), participates in signaling tau...

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PMID: 21347278
DOI: 10.1371/journal.pgen.1001299
PMCID: PMC3037409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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