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ALDH3A2 acts as a metabolic safeguard that regulates sphingolipid metabolism to suppress DNA damage and cell death

2026-07-31

Abstract excerpt

Highly reactive aldehydes are generated during metabolic processes in the body, and their detoxification is essential for maintaining cellular homeostasis. Hexadecenal, a long-chain fatty aldehyde, is formed during the sphingolipid degradation pathway from the lipid mediator sphingosine-1-phosphate (S1P). However, the cytotoxicity resulting from dysregulation of hexadecenal metabolism is still unclear. To elucidat...

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Literature Corpus work
b4ce8296-fc23-5b4e-b539-1347e2a75da3
DOI
10.64898/2026.07.31.741968
Open publication

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ALDH3A2 acts as a metabolic safeguard that regulates sphingolipid metabolism to suppress DNA damage and cell deathDOI 10.64898/2026.07.31.741968
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