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Article

Functional characterization of TMEM86A and TMEM86B mutants by a novel lysoplasmalogenase assay.

Journal of lipid research - 1 Apr 2025

Kummer Denise, Dorigatti Ilaria, Dunzendorfer-Matt Theresia, Golderer Georg, Werner Ernst R, Watschinger Katrin

Abstract excerpt

Plasmalogens are an abundant class of glycero-phospholipids with a characteristic 1-O-alk-1'-enyl double bond. While their synthesis has been extensively investigated, their degradation remains understudied. Plasmalogen deficiencies are associated with severe disorders in humans and interfering with their degradation would be a treatment option, but it remains out of reach due to limited knowledge. The...

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Identifiers

PMID: 40024572
DOI: 10.1016/j.jlr.2025.100766
PMCID: PMC11994398

Genes

TMEM86A
TMEM86B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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